Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation on an underground arms cache in Syria employed by the Islamic State group (IS), according to the UK Ministry of Defence.
The location, pinpointed through surveillance, was thought to be housing weapons and explosive materials, the statement said, and was located in mountainous terrain just to the north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to strike a series of approach shafts down to the site... early reports are that the objective was successfully hit," officials stated.
There was no indication of any civilian impact in the attack late on Saturday and every plane involved returned to base without incident, the MoD added.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
Daesh - referred to as ISIS - imposed extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This strike underscores British leadership, and determination to operate in unison with allied nations, to stamp out any revival of Daesh and their dangerous and violent ideologies in the area," the British Defence Secretary the Defence Secretary said.
British military aircraft have conducted patrols over Syrian airspace to "forestall any efforts to regroup" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank the personnel of our armed forces involved in this operation for their skill and their valour," he said. "They were among thousands of British troops on duty over the holidays. This operation, to take out dangerous terrorists who pose a risk to our safety, highlights how British military are always on standby, continuously, protecting the UK domestically and influential overseas."
During December, the United States armed forces conducted what it described as a "massive strike" on Daesh sites in Syria, after an attack killed two US servicemembers and a local interpreter in Palmyra.
The United Nations says Islamic State still maintains between 5,000 and 7,000 militants in both countries.
